In general, it takes about three months for your body to adjust to Depo Provera. Similar to other hormonal birth control methods, your body needs to get used to the hormone (progestin).
As your body is adjusting to Depo Provera, it is likely that you will experience irregular bleeding (spotting) and/or prolonged bleeding (like a continuous period). This reaction is considered completely normal. If, however, you notice that your bleeding is very heavy or if you are concerned, it is important to contact your health-care provider (See: Depo Bleeding – Will It Ever Stop?).
- Other side effects that you may experience include: skin reactions, weight gain, and pain (associated with the actual injection).
- Less common side effects include: change in sex drive, depression, nervousness, dizziness, nausea, change of appetite, headaches, skin rash or spotty darkening of the skin, sore breasts, hair loss and/or increased hair on the face or body.
It is also recommended that you make an appointment for your next scheduled injection during the same doctor’s visit that you receive your first shot.
- If you are using the original Depo Provera shot, make your appointment for your second injection within 11 to 13 weeks.
- If you are using the newer Depo-subQ Provera 104, your next shot should be in 12 to 14 weeks.