1. Health
You can opt-out at any time. Please refer to our privacy policy for contact information.

Guide to What to Expect During the First Year of Depo Provera Use


Updated July 02, 2014

3 of 6

Second Dose – Month’s 4 - 6
Guide to What to Expect During the First Year of Depo Provera Use

Depo Provera Shot Reminder

Photo Courtesy of Dawn Stacey
After your second Depo Provera shot or Depo-subQ 104 injection, your body will still be adjusting to the hormone. By now, you have probably been happy with the convenience of not having to think about birth control.

During months four through six, it is still considered normal if you are experiencing sporadic bleeding. Most women who have used this method report that the irregular spotting tends to lessen with each shot. In fact, by the end of month six, 39 percent of women usually have had their periods stop completely.

At this point, you may or may not have noticed changes to your weight. If you have yet to do so, use this doctor’s visit to discuss a possible exercise and/or diet plan with your doctor. Pfizer maintains that if you eat sensibly and exercise often, you can help reduce the changes in your weight that may stem from Depo Provera use.

It is also important to find out from your doctor what you should be doing to adopt a lifestyle that can help maintain bone health (due to the black box warning that Depo Provera use may cause bone mineral density loss). Ask your doctor about recommendations concerning adequate calcium intake through supplements and vitamin D, a diet containing lots of vegetables, and weight-bearing and muscle-strengthening exercises that may help aid in countering any potential calcium loss to your bones. Your doctor may also suggest that you stop smoking (if you are a smoker) and to limit or cut out any alcohol consumption.

Make an appointment for your next scheduled injection during the same doctor’s visit that you receive your second shot.

  • If you are using the original Depo Provera shot, make your appointment for your third injection within 11 to 13 weeks.

  • If you are using the newer Depo-subQ Provera 104, your next shot should be in 12 to 14 weeks.
This will ensure that your pregnancy protection continues.

©2014 About.com. All rights reserved.

We comply with the HONcode standard
for trustworthy health
information: verify here.